Biological Variation of Donor-Derived Cell-Free DNA in Renal Transplant Recipients: Clinical Implications

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Biological Variation of Donor-Derived Cell-Free DNA in Renal Transplant Recipients: Clinical Implications

Background: Previous studies have demonstrated that donor-derived cell-free DNA (dd-cfDNA) found in circulating blood of transplant recipientsmay serve as a noninvasive biomarker of allograft rejection. To better interpret the clinicalmeaning of dd-cfDNA, it is essential to understand the biological variation of this biomarker in stable healthy recipients. This report establishes the biological...

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Presence of donor- and recipient-derived DNA in cell-free urine samples of renal transplantation recipients: urinary DNA chimerism.

BACKGROUND Previous studies have indicated that microchimerism is present in body tissues, peripheral blood, and plasma of recipients after organ transplantation. We hypothesize that donor-derived DNA may also be present in cell-free urine of renal transplant recipients and that the concentrations of urine DNA may be correlated with graft rejection. METHODS Thirty-one female patients who had ...

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ژورنال

عنوان ژورنال: The Journal of Applied Laboratory Medicine: An AACC Publication

سال: 2017

ISSN: 2475-7241

DOI: 10.1373/jalm.2016.022731